HS68 Fibroblast data
at the University of Virginia

HS68 Fibroblast data

In order to investigate whether the capacity to signal fibroblasts and alter host gene expression profiles is correlated to the invasive potential of specific human melanoma cell lines we assayed changes in gene expression of fibroblasts when co-cultured with the human melanoma cell lines BLM, MV3, A2058, SK-mel28 and WM164. Granted that genes who differentially expressed in fibroblasts co-cultured with highly invasive/metastatic melanoma compared with that of co-cultured with non invasive/metastatic melanoma are very likely associated with invasive signaling communicating between fibroblasts and melanoma, we compared the profiling between fibroblasts co-cultured with these two categories of melanoma as represented by BLM and MV3 lines and the WM164 line.


Genes with fold change <0.5 in fibroblasts co-cultured with BLM and MV3 and fold change ≥ 2 in fibroblasts co-cultured with WM164 were listed.

Genes whose expression increased (fold change ≥ 2) in both the fibroblasts co-cultured with BLM or MV3 and decreased (fold change <0.5) in fibroblasts co-cultured with WM164 cell line were listed.

Contact Information

Jay W Fox jwf8x@virginia.edu
Ling Li ll9j@virginia.edu
University of Virginia School of Medicine
Department of Microbiology

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