TOBFAC: The database of tobacco transcription factors
Family: Dof
Minimum number of tobacco C2C2-Dof genes: 46
Count of tobacco C2C2-Dof sequences: 48
Pfam accession: zf-Dof
SHOULD possess zf-Dof domain
Dof (DNA-binding with one finger) domain proteins are plant-specific transcription factors with a highly conserved DNA-binding domain, which presumably includes a single C(2)-C(2) zinc finger. During the past decade, numerous Dof domain proteins have been identified in both monocots and dicots including maize, barley, wheat, rice, tobacco, Arabidopsis, pumpkin, potato, and pea. Biochemical, molecular biological and molecular genetic analyses revealed that Dof domain proteins function as a transcriptional activator or a repressor involved in diverse plant-specific biological processes. Although more physiological roles of Dof domain proteins would be elucidated in future because of numerous Dof domain proteins in plants, it is already evident that the Dof domain proteins play critical roles as transcriptional regulators in plant growth and development.
Yanagisawa S Dof domain proteins: Plant-specific transcription factors associated with diverse phenomena unique to plants PLANT AND CELL PHYSIOLOGY 45 (4): 386-391 2004 PMID: 15111712
Yanagisawa S, Akiyama A, Kisaka H, Uchimiya H, Miwa T Metabolic engineering with Dof1 transcription factor in plants: Improved nitrogen assimilation and growth under low-nitrogen conditions PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (20): 7833-7838 2004 PMID: 15136740
Umemura Y, Ishiduka T, Yamamoto R, Esaka M The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain PLANT JOURNAL 37 (5): 741-749 2004 PMID: 14871313
Baumann,K., De Paolis,A., Costantino,P. and Gualberti,G. The DNA binding site of the Dof protein NtBBF1 is essential for tissue-specific and auxin-regulated expression of the rolB oncogene in plants PLANT CELL 11 (3): 323-334 1999 PMID: 10072394
De Paolis,A., Sabatini,S., De Pascalis,L., Costantino,P. and Capone,I. A rolB regulatory factor belongs to a new class of single zinc finger plant proteins PLANT JOURNAL 10 (2): 215-223 1996 PMID: 8771779
Lijavetzky, D; Carbonero, P; Vicente-Carbajosa, J. Genome-wide comparative phylogenetic analysis of the rice and Arabidopsis Dof gene families. BMC Evol. Biol. 2003. 3:17 PMID: 12877745
Number of N terminal - 3
Number of C terminal - 3
Number of full – 43
Total minimum number – 46
| Family | Genbank ID | Name |
| Dof | AJ009594 | BBF1 |
| Dof | X97947 | BBF3 |
| Dof | X97946 | NtBBF2b |
| Dof | X97945 | NtBBF2a |
| Dof | X97942 | NtBBF1.1 |
Paul J Rushton
Marta T. Bokowiec
Xianfeng (Jeff) Chen
Thomas (Tom) W Laudeman
Jennifer F. Brannock
Michael P. Timko
