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TOBFAC: The database of tobacco transcription factors

Family: FHA

Minimum number of tobacco FHA genes: 12

Count of tobacco FHA sequences: 12

Pfam accession: FHA

The forkhead-associated (FHA) domain is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognise phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich, which sometimes contain small helical insertions between the loops connecting the strands.

To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not archaeal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes - DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples.

Papers

Kim M, Ahn JW, Song K, Paek KH, Pai HS. Forkhead-associated domains of the tobacco NtFHA1 transcription activator and the yeast Fhl1 forkhead transcription factor are functionally conserved. J Biol Chem. 2002 Oct 11;277(41):38781-90. Epub 2002 Jul 30. PMID: 12149245

Number of contigs: 8

Number of singlets: 7

Number of N terminal – 4

Number of C terminal – 0

Number of full – 8

Total minimum number – 12

Search sequences and info

Transcription factor sequences

Tobacco published genes related to transcription factor family FHA

Authors of this site:

Paul J Rushton
Marta T. Bokowiec
Xianfeng (Jeff) Chen
Thomas (Tom) W Laudeman
Jennifer F. Brannock
Michael P. Timko

Contact:

pr8y@virginia.edu