FHA Genomic sequences

Minimum number of tobacco FHA genes: 12

Count of tobacco FHA sequences: 12

Pfam accession: FHA

The forkhead-associated (FHA) domain is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognise phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich, which sometimes contain small helical insertions between the loops connecting the strands.

To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not archaeal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes - DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples.

Papers

Kim M, Ahn JW, Song K, Paek KH, Pai HS. Forkhead-associated domains of the tobacco NtFHA1 transcription activator and the yeast Fhl1 forkhead transcription factor are functionally conserved. J Biol Chem. 2002 Oct 11;277(41):38781-90. Epub 2002 Jul 30. PMID: 12149245



Number of contigs: 8

Number of singlets: 7

Number of N terminal – 4

Number of C terminal – 0

Number of full – 8

Total minimum number – 12




Search sequences and info


Transcription factor sequences
Locus
Description
NCBI
FHA_1 [comment=N terminal] ET047877
ET047878
FHA_2 [comment=full] ET049849
ET042921
ET051831
FHA_3 [comment=full] ET050597
ET049507
ET046203
ET044118
FHA_4 [comment=full is NtFHA1] ET047963
ET046030
ET046031
ET048382
ET045149
FHA_5 [comment=full] ET046973
ET043351
ET045187
ET046021
ET047613
ET047328
FHA_6 [comment=N terminal] ET042313
ET043192
ET043117
ET045298
ET046519
ET043193
ET045299
FHA_7 [comment=full] ET050726
ET049140
ET042521
ET042130
ET051741
ET044519
ET042131
FHA_8 [comment=full] ET046408
FHA_9 [comment=full] ET047734
FHA_10 [comment=N terminal] ET051560
FHA_11 [comment=full] ET046314
FHA_12 [comment=N terminal] ET046676


Tobacco published genes related to transcription factor family FHA
Family Genbank ID Name
FHA AF411856 NtFHA1
Authors of this site:

Paul J Rushton
Marta T. Bokowiec
Xianfeng (Jeff) Chen
Thomas (Tom) W Laudeman
Jennifer F. Brannock
Michael P. Timko

Contact:

pr8y@virginia.edu