TOBFAC: The database of tobacco transcription factors
Family: JUMONJI
Minimum number of tobacco JUMONJI genes: 18
Count of tobacco JUMONJI sequences: 23
SHOULD possess JmjC JmjN zf-C2H2 zf-C5HC2 domains and COULD possess PHD domain
JUMONJI (JMJ) is a nuclear protein that is critical for normal cardiovascular development by characterizing JMJ knockout mice. The jmj mutant embryos showed heart malformations including ventricular septal defect, noncompaction of the ventricular wall, double outlet right ventricle, and dilated atria. All homozygous jmj mutants died soon after birth. Cardiac marker analysis by in situ hybridization suggested that cardiomyocytes were differentiated but developmental regulation of chamber-specific genes was defective in late stage embryos.
The jmj gene was first identified and described as a developmentally important gene in the nervous system and subsequently in liver, spleen, and thymus development, when knockout mice were generated in genetic backgrounds that are different from ours. During mouse embryonic development, JMJ is widely expressed, including in the developing heart. In adult mice, it is expressed at a higher level in heart, skeletal muscle, brain, and thymus. Continuous expression of jmj in the heart suggests that JMJ plays an important role in both the developing and adult heart. Although JMJ may be involved in cell growth when JMJ is overexpressed, the molecular function of JMJ remains unknown. The deduced amino acid sequence of JMJ reveals a putative DNA binding domain (DBD) homologous to the DBD of a DNA-binding protein family, AT-rich interaction domain (ARID), suggesting that JMJ is a transcription factor. However, the homology of this domain with the DBDs of other ARID family members is low, with only about 30% amino acid identity in the putative DBD. There is an increasing number of factors that belong to an ARID family, which show diverse functions in vertebrates, plants, and fungi.
Balciunas, D; Ronne, H. Evidence of domain swapping within the jumonji family of transcription factors. Trends Biochem. Sci. 2000. 25(6):274-6 PMID: 10838566
Kim, TG; Kraus, JC; Chen, J; Lee, Y. JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor. J. Biol. Chem. 2003. 278(43):42247-55 PMID: 12890668
Takeuchi, T; Watanabe, Y; Takano-Shimizu, T; Kondo, S. Roles of jumonji and jumonji family genes in chromatin regulation and development. Dev. Dyn. 2006 Sep;235(9):2449-59 PMID: 16715513
Number of contigs: 11
Number of singlets: 15
Number of N terminal – 11
Number of C terminal – 5
Number of full – 7
Total minimum number – 18
| Family | Genbank ID | Name |
Paul J Rushton
Marta T. Bokowiec
Xianfeng (Jeff) Chen
Thomas (Tom) W Laudeman
Jennifer F. Brannock
Michael P. Timko