LUG Genomic sequences

Minimum number of tobacco LUG genes: 2

Count of tobacco LUG sequences:

Pfam accession: LUFS

SHOULD possess LUFS domain

Regulation of homeotic gene expression is critical for proper developmental patterns in both animals and plants. LEUNIG is a key regulator of the Arabidopsis floral homeotic gene AGAMOUS. Mutations in LEUNIG cause ectopic AGAMOUS mRNA expression in the outer two whorls of a flower, leading to homeotic transformations of floral organ identity as well as loss of floral organs. We isolated the LEUNIG gene by using a map-based approach and showed that LEUNIG encodes a glutamine-rich protein with seven WD repeats and is similar in motif structure to a class of functionally related transcriptional corepressors including Tup1 from yeast and Groucho from Drosophila. The nuclear localization of LEUNIG-GFP is consistent with a role of LEUNIG as a transcriptional regulator. The detection of LEUNIG mRNA in all floral whorls at the time of their inception suggests that the restricted activity of LEUNIG in the outer two floral whorls must depend on interactions with other spatially restricted factors or on posttranslational regulation. Our finding suggests that both animals and plants use similar repressor proteins to regulate critical developmental processes.


Conner, J; Liu, Z. LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS expression during flower development. Proc. Natl. Acad. Sci. U.S.A. 2000. 97(23):12902-7 PMID: 11058164

Number of contigs: 6

Number of singlets: 0

Number of N terminal – 4

Number of genes with middle part of domain – 2

Total minimum number – 2

Search sequences and info

Transcription factor sequences
LUG_1 [comment=5 prime end] ET046435
LUG_2 [comment=5 prime end] ET043215
LUG_3 [comment=5 prime end] ET051325
LUG_4 [comment=5 prime end] ET043303
LUG_5 [comment=middle] ET048108
LUG_6 [comment=middle] ET051324

Tobacco published genes related to transcription factor family LUG
Family Genbank ID Name
Authors of this site:

Paul J Rushton
Marta T. Bokowiec
Xianfeng (Jeff) Chen
Thomas (Tom) W Laudeman
Jennifer F. Brannock
Michael P. Timko