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TOBFAC: The database of tobacco transcription factors

Family: MYB-related

Minimum number of tobacco MYB-related genes: 56

Count of tobacco MYB-related sequences: 62

Pfam accession: Myb_DNA-binding

SHOULD possess Myb_DNA-binding domain and COULD   possess zf-CCHC domain but SHOULD NOT possess ARID G2-like Response_reg SNF2_N domains

The cloning of the first transcription factor from plants, the C1 gene of maize, indicated that plants use transcription factors that are structurally related to those of animals in their control of gene expression, because C1 showed significant structural homology to the vertebrate cellular proto-oncogene c-MYB. Since 1987, the catalogue of MYB-related transcription factors has increased considerably in size due, primarily, to the ever-expanding number of MYB genes identified in higher plants (Arabidopsis thaliana is estimated to contain more than a hundred MYB genes). In vertebrates, the MYB-related proto-oncogenes comprise a small family with a central role in controlling cellular proliferation and commitment to development. However, while the functions of some plant MYB genes are relatively well understood they are, at present, quite distinct from their animal counterparts.

Papers

Jin, H; Martin, C. Multifunctionality and diversity within the plant MYB-gene family. Plant Mol. Biol. 1999. 41(5):577-85 PMID: 10645718

Klempnauer, KH; Sippel, AE. The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain. EMBO J. 1987. 6(9):2719-25 PMID: 2824190

Martin, C; Paz-Ares, J. MYB transcription factors in plants. Trends Genet. 1997. 13(2):67-73 PMID: 9055608

Kirik V, Baumlein H. A novel leaf-specific myb-related protein with a single binding repeat Gene. 1996 Dec 12;183(1-2):109-13. PMID: 8996094

All have 20 amino acids in until the middle except the last two categories. Hence the total of 56 minimum.

Searched with over 10 individual MYB-related domains from Arabidopsis.

n.b Genes that contain only a single canonical R3 domain have been grouped with the R2R3MYBS. The MYB-related category here only represents divergent single domains.

We consider R2 domains with the sequence GKSCRLRW and

R3 domains with the sequence LPGRTDN not to be MYB-related.

These two are in our R2R3MYB category and are not among the MYB-related genes in DATB.

Number of contigs: 71

Number of singlets: 19

Number of N terminal – 4

Number of genes with missing less than 20 amino acids at 5’ end – 11

Number of genes with first 60% – 2

Number of genes with missing less than 20 amino acids 3’ end – 10

Number of C terminal – 4

Number of genes with first 20 amino acids – 2

Number of full – 28

Total minimum number – 56

Search sequences and info

Transcription factor sequences

Tobacco published genes related to transcription factor family MYB-related

Authors of this site:

Paul J Rushton
Marta T. Bokowiec
Xianfeng (Jeff) Chen
Thomas (Tom) W Laudeman
Jennifer F. Brannock
Michael P. Timko

Contact:

pr8y@virginia.edu