TOBFAC: The database of tobacco transcription factors
Family: NAC
Minimum number of tobacco NAC genes: 152
Count of tobacco NAC sequences: 203
Pfam accession: NAM
SHOULD possess NAM domain
The NAC (NAM, ATAF1,2, CUC2) gene family is one of the largest families of plant specific transcription factors . It’s members have been implicated in regulating diverse processes including flower development and reproduction, defence, abiotic stress responses and responses to hormones . The first NAC gene to be described was no apical meristem (NAM) from petunia . Plants harbouring this mutation lack a shoot apical meristem, as do plants with mutations in both CUP-SHAPED COTYLEDON 2 (CUC2) and CUC1. NAC1 plays a role in lateral root formation and auxin signaling and TIP functions in a resistance response pathway and interacts with the turnip crinkle virus capsid protein inducing a hypersensitive response . The NAC family members are defined by the presence of the NAC domain, a conserved DNA-binding domain that appears to have no known close structural homologues . The NAC domain is found in the N-terminal region of NAC proteins and X-ray crystallography show that it consists of a twisted anitparallel -sheet that packs against an N-terminal -helix on one side and a short helix on the other side . As well as DNA binding, the NAC domain also appears to be involved in dimerisation and NAC proteins have been shown to homo- and heterodimerise .
Olsen, AN; Ernst, HA; Leggio, LL; Skriver, K. NAC transcription factors: structurally distinct, functionally diverse. Trends Plant Sci. 2005. 10(2):79-87 PMID: 15708345
Ooka, H; Satoh, K; Doi, K; Nagata, T; Otomo, Y; Murakami, K; Matsubara, K; Osato, N; Kawai, J; Carninci, P; Hayashizaki, Y; Suzuki, K; Kojima, K; Takahara, Y; Yamamoto, K; Kikuchi, S. Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana. DNA Res. 2003. 10(6):239-47 PMID: 15029955
Xie, Q; Frugis, G; Colgan, D; Chua, NH. Arabidopsis NAC1 transduces auxin signal downstream of TIR1 to promote lateral root development. Genes Dev. 2000. 14(23):3024-36 PMID: 11114891
Duval M, Hsieh TF, Kim SY, Thomas TL Molecular characterization of AtNAM: a member of the Arabidopsis NAC domain superfamily. Plant Mol Biol. 2002 Sep;50(2):237-48. PMID: 12175016
Number of contigs: 180
Number of singlets: 27
Number of A and B domains – 53
Number of C domains – 52
Number of full – 98
Total minimum number - 152 (151 + TERN – published NAC gene)
| Family | Genbank ID | Name |
| NAC | AB021178 | TERN |
Paul J Rushton
Marta T. Bokowiec
Xianfeng (Jeff) Chen
Thomas (Tom) W Laudeman
Jennifer F. Brannock
Michael P. Timko
