PcG Genomic sequences

Minimum number of tobacco PcG genes: 20

Count of tobacco PcG sequences: 39

Pfam accession:

Polycomb group (PcG) proteins maintain silencing at target loci in higher eukaryotes but recent evidence suggests that about half of these proteins are also required for maintenance of activation at homeotic loci.

The best-studied proteins required for the maintenance but not initiation of repression of target loci are encoded by genes of the Polycomb group (PcG). PcG mutants exhibit posterior transformations in embryos and adults caused by derepression of homeotic loci in flies [1], and in vertebrates [2]. In addition, PcG genes regulate non-homeotic targets. In contrast, proteins of the trithorax group (trxG) are required for maintenance but not initiation of activation of homeotic loci [3]. Many genes in the trxG were identified because they suppress phenotypes of PcG mutations, suggesting that the trxG proteins act antagonistically to PcG proteins [4]. Structural analysis of PcG and trxG response elements shows that the elements required for trxG-dependent activation and PcG-dependent repression are separable but within 30¨C40 bp of each other. This intermingling of elements required for activation and repression in DNA sequences previously termed PcG response elements (PREs) or trxG response elements (TREs) leads us to propose that DNA sequences required for maintenance of gene regulation be named ¡®maintenance elements¡¯ in recognition of their dual function. How maintenance of gene expression is achieved is unknown at present but new evidence supports the idea that there may be overlap between mechanisms of PcG and trxG modification of chromatin and the chromatin condensation that occurs prior to mitosis.

Papers

Brock HW, van Lohuizen M. The Polycomb group--no longer an exclusive club? Curr Opin Genet Dev. 2001 Apr;11(2):175-81. PMID: 11250141



Number of contigs: 25

Number of singlets: 21

Number of N terminal – 9

Number of C terminal – 14

Number of full – 6

Number of genes with middle bit – 10

Total minimum number – 20




Search sequences and info


Transcription factor sequences
Locus
Description
NCBI
PcG_1 [comment=C terminal] ET042061
PcG_2 [comment=C terminal] ET045539
PcG_3 [comment=C terminal] ET046713
ET043017
PcG_4 [comment=C terminal] ET045295
ET044028
PcG_5 [comment=C terminal] ET042846
ET042847
PcG_8 [comment=C terminal] ET047725
ET050215
PcG_9 [comment=C terminal] ET044584
ET048352
PcG_11 [comment=C terminal] ET041843
ET041844
PcG_12 [comment=full] ET044660
ET050076
PcG_14 [comment=C terminal] ET050891
ET043175
PcG_15 [comment=N terminal] ET045802
ET041971
ET044624
PcG_16 [comment=N terminal] ET049529
ET043176
ET043532
PcG_17 [comment=full] ET045331
ET048486
ET051356
PcG_20 [comment=C terminal] ET048968
ET051696
ET050208
PcG_21 [comment=C terminal] ET044790
ET047599
ET044791
PcG_22 [comment=N terminal] ET049699
ET041780
ET041779
ET051040
PcG_23 [comment=middle bit] ET048952
ET051385
ET050797
ET051824
ET047360
PcG_24 [comment=full] ET049667
ET042125
ET042250
ET042126
ET049668
PcG_25 [comment=full] ET047345
ET042247
ET043903
ET043078
ET049587
ET044955
ET043079
PcG_26 [comment=N terminal] ET047962
PcG_27 [comment=N terminal] ET044661
PcG_28 [comment=C terminal] ET043276
PcG_29 [comment=N terminal] ET046714
PcG_30 [comment=N terminal (very small fragment)] ET045441
PcG_31 [comment=C terminal] ET051892
PcG_32 [comment=middle bit] ET049619
PcG_33 [comment=middle bit] ET048832
PcG_34 [comment=middle bit] ET048024
PcG_35 [comment=middle bit] ET043781
PcG_36 [comment=middle bit] ET048023
PcG_37 [comment=middle bit] ET049468
PcG_38 [comment=middle bit] ET042332
PcG_39 [comment=N terminal] ET047142
PcG_40 [comment=full] ET043506
PcG_41 [comment=N terminal] ET047787
PcG_42 [comment=C terminal] ET042946
PcG_43 [comment=middle bit] ET049770
PcG_44 [comment=middle bit] ET043289
PcG_45 [comment=full] ET047741


Tobacco published genes related to transcription factor family PcG
Family Genbank ID Name
Authors of this site:

Paul J Rushton
Marta T. Bokowiec
Xianfeng (Jeff) Chen
Thomas (Tom) W Laudeman
Jennifer F. Brannock
Michael P. Timko

Contact:

pr8y@virginia.edu