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TOBFAC: The database of tobacco transcription factors

Family: R2R3-MYB

Minimum number of tobacco R2R3MYB genes: 194

Count of tobacco R2R3MYB sequences: 223

Pfam accession: Myb_DNA-binding

SHOULD possess Myb_DNA-binding domain but SHOULD NOT possess ARID Response_reg SNF2_N domains

The MYB family of transcription factors is the largest family of transcription factors in many plant species and it is estimated that MYBs make up approximately one eighth of the known transcription factors in Arabidopsis . MYB genes have been identified in almost all eukaryotes and are defined by the presence of one or more MYB DNA-binding domains. This domain comprises of up to three imperfect repeats, each forming a helix-turn-helix structure of about 53 amino acids . In plants, the MYB family is divided into the the R1R2R3, R2R3, RAV and MYB-related families, that have three, two or one MYB domains . The MYB-related proteins are fairly divergent and include transcriptional activators that are associated with the circadian clock such as CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY). Tobacco contains a minimum of 56 MYB-related genes (Table 1). The largest MYB subfamily is the R2R3MYB family and these appear to be only present in plants where they are predominately involved in “plant specific” processes such as the regulation of plant secondary metabolism and the identity and fate of plant cells .

Papers

Jin, H; Martin, C. Multifunctionality and diversity within the plant MYB-gene family. Plant Mol. Biol. 1999. 41(5):577-85 PMID: 10645718

Klempnauer, KH; Sippel, AE. The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain. EMBO J. 1987. 6(9):2719-25 PMID: 2824190

Martin, C; Paz-Ares, J. MYB transcription factors in plants. Trends Genet. 1997. 13(2):67-73 PMID: 9055608

Stracke, R; Werber, M; Weisshaar, B. The R2R3-MYB gene family in Arabidopsis thaliana. Curr. Opin. Plant Biol. 2001. 4(5):447-56 PMID: 11597504

Yanhui, C; Xiaoyuan, Y; Kun, H; Meihua, L; Jigang, L; Zhaofeng, G; Zhiqiang, L; Yunfei, Z; Xiaoxiao, W; Xiaoming, Q; Yunping, S; Li, Z; Xiaohui, D; Jingchu, L; Xing-Wang, D; Zhangliang, C; Hongya, G; Li-Jia, Q. The MYB Transcription Factor Superfamily of Arabidopsis: Expression Analysis and Phylogenetic Comparison with the Rice MYB Family. Plant Mol Biol 2006. 60(1):107-124 PMID: 16463103

Number of contigs: 200

Number of singlets: 30

Number of N terminal – 38

Number of C terminal – 51

Number of full – 134

There are 9 published R2R3MYB genes that did not appear in GSSs and were added to the data set manually.

Total minimum number – 194

Search sequences and info

Transcription factor sequences

Tobacco published genes related to transcription factor family R2R3-MYB

Authors of this site:

Paul J Rushton
Marta T. Bokowiec
Xianfeng (Jeff) Chen
Thomas (Tom) W Laudeman
Jennifer F. Brannock
Michael P. Timko

Contact:

pr8y@virginia.edu