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TOBFAC: The database of tobacco transcription factors

Family: bZIP

Minimum number of tobacco bZIP genes: 75

Count of tobacco bZIP sequences: 75

Pfam accession: bZIP_1 bZIP_2

SHOULD possess bZIP_1 bZIP_2 domains but SHOULD NOT possess HLH domain

Basic region/leucine zipper (bZIP) transcription factors play roles in a large number of biological processes and bZIP genes appear to be present in all eukaryotes . bZIP proteins are defined by the basic region/leucine zipper motif, with the basic region being responsible for DNA binding and the leucine zipper for dimerisation. The bZIP domain contains these two structural features on a contiguous -helix with the basic region of about 16 amino acids containing a nuclear localization signal followed by an invariant N-X7-R/K motif that contacts the DNA. The leucine zipper contains a heptad repeat of leucines or other bulky hydrophobic amino acids that creates an amphipathic helix and two of these zipper motifs adhere and create a coiled coil structure . Leucine zippers are also found in a number of other transcription factors such as WRKY transcription factors .

bZIP genes in plants have been implicated in regulating important processes such as defence against pathogens, light and stress signaling, seed maturation and flower development . The 75 bZIP genes that have been identified in the Arabidopsis genome have been divided into 10 groups based on the sequence of the basic region and additional conserved motifs . This classification was not based purely on phylogeny and emphasized conserved motifs outside of the bZIP domain.

Cormack, R.S., Eulgem, T., Rushton, P.J., Kochner, P., Hahlbrock, K., and Somssich, I.E. Leucine zipper-containing WRKY proteins widen the spectrum of immediate early elicitor-induced WRKY transcription factors in parsley. Biochimica Et Biophysica Acta-Gene Structure and Expression 1576: 92-100 2002

Papers

Foster, R; Izawa, T; Chua, NH. Plant bZIP proteins gather at ACGT elements. FASEB J. 1994 8(2):192-200 PMID: 8119490

Hurst, HC. Transcription factors 1: bZIP proteins. Protein Profile 1995. 2(2):101-68 PMID: 7780801

Landschulz, WH; Johnson, PF; McKnight, SL. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 1988. 240(4860):1759-64 PMID: 3289117

Vinson, C; Acharya, A; Taparowsky, EJ. Deciphering B-ZIP transcription factor interactions in vitro and in vivo. Biochim. Biophys. Acta 2006. 1759(1-2):4-12 PMID: 16580748

Jakoby, M; Weisshaar, B; Droge-Laser, W; Vicente-Carbajosa, J; Tiedemann, J; Kroj, T; Parcy, F; bZIP Research Group. bZIP transcription factors in Arabidopsis Trends Plant Sci 2002. 7(3):106-11 PMID: 11906833

Schindler, U; Beckmann, H; Cashmore, AR. TGA1 and G-box binding factors: two distinct classes of Arabidopsis leucine zipper proteins compete for the G-box-like element TGACGTGG. Plant Cell 1992.4(10):1309-19 PMID: 1446171

Number of contigs: 102

Number of singlets: 37

Number of N terminal – 7

Number of C terminal – 6

Number of full – 47

There are 8 published genes that did appear in the GSSs search and 13 that did not appear in the search. All these genes were added to the data set under their published names.

Total minimum number – 75

Search sequences and info

Transcription factor sequences

Tobacco published genes related to transcription factor family bZIP

Authors of this site:

Paul J Rushton
Marta T. Bokowiec
Xianfeng (Jeff) Chen
Thomas (Tom) W Laudeman
Jennifer F. Brannock
Michael P. Timko

Contact:

pr8y@virginia.edu